One of the great challenges in genetics and nutrition is to understand how each individual interacts with, and responds to their environment. Diet is the most important environmental factor influencing expression of genetic information because of the constant exposure to nutrients in foods. The emerging discipline of nutritional genomics or nutrigenomics is the study of the effects of diet on the activity of an individual’s genes and health and the study of how different genetic makeup metabolizes nutrients. Few if any have been trained in the many disciplines used in this research and its potential applications. This course provides the fundamental concepts of technologies and strategies for conducting and understanding nutritional genomic research. It is divided into nine sections: overview; DNA; RNA; proteomics and detection systems; bioinformatics; genetics; SNPs; model systems; and ethics.