The world of microbes is higly diverse. Each prokaryotic species has its own uniqueness, usually connected to its adaptation in the living environment. This course will introduce examples of various unique prokaryotes to students as well as their potential application. This course is also completed with laboratory activities, where students may have their own experience in dealing with those microbes. Lab topics include bacterial cellulose formation, ice nucleating bacterias, quorum sensing, bioluminescens, and bacterial diversity analysis using ERIC-PCR.